Assessing the Impact of COVID-19 Inactivated Vaccination Doses on Male Fertility in Assisted Insemination with Husband's Sperm (AIH) Cycle

Abstract

Background: This study aimed to assess the impact of coronavirus disease 2019 (COVID-19) inactivated vaccination doses on male fertility.

Methods. A retrospective cohort study was conducted, including 595 assisted inseminations with husband's sperm (AIH) cycles involving 438 couples. Participants were categorized into three groups: the unvaccinated group, the 1 or 2 doses group, and the 3 doses group based on their vaccination status before insemination. Reproductive outcomes such as biochemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth were assessed across the different groups.

Results: The analysis revealed no significant differences in reproductive outcomes among the three groups. The rates of biochemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth were comparable among the unvaccinated group, the 1 or 2 doses group, and the 3 doses group (P=0.433, P=0.637, P=0.583, and P=0.539, respectively). Multivariate logistic regression analysis indicated that the doses of COVID-19 inactivated vaccine did not independently impact the reproductive outcomes of AIH cycles.

Conclusion: The administration of COVID-19 inactivated vaccine doses did not adversely affect male fertility in AIH cycles.