Effect Of Female Covid-19 Inactivated Vaccination Doses on Cycle Outcome of Artificial Insemination with Husband Semen

Abstract

Background: This study aimed to investigate the impact of different doses of COVID-19 inactivated vaccine on female fertility.

Materials and Methods: A total of 595 assisted insemination with husband's sperm (AIH) cycles were retrospectively analyzed in this cohort study. The participants were divided into three groups: the unvaccinated group, the 1 or 2 doses group, and the 3 doses group based on their COVID-19 vaccination status prior to insemination. Reproductive outcomes, including biochemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth, were assessed across the three groups.

Results: The analysis revealed no significant differences in reproductive outcomes among the three groups. The rates of biochemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth were comparable among the unvaccinated group, the 1 or 2 doses group, and the 3 doses group (P=0.369, P=0.975, P=0.686, and P=0.441, respectively). The Multivariate logistic regression analysis indicated that the doses of COVID-19 inactivated vaccine did not independently impact the reproductive outcomes of AIH cycles.

Conclusion: The findings suggest that the doses of COVID-19 inactivated vaccine do not have a detrimental effect
on female fertility in AIH cycles.