Efficacy of Subcutaneous Administration of Granulocyte Colony-Stimulating Factor in Patients with Recurrent Implantation Failure in Frozen-Thawed Embryo Transfer Cycles

Abstract

Objective: To investigate the effect of the subcutaneous administration of G-CSF on pregnancy outcomes in patients with RIF before and after FET.

Methods: This retrospective study included 170 patients who underwent FET at the Center for Reproduction and Genetics of The First Affiliated Hospital of USTC, Hefei, China, from January 1, 2021, to December 31, 2022. Seventy-five of them were administered G-CSF, and the others received no specific treatment. The clinical pregnancy rate, embryo implantation rate, biochemical pregnancy rate, abortion rate, and live birth rate of both groups were calculated by SPSS software.

Results: The clinical pregnancy rate, embryo implantation rate, biochemical pregnancy rate, abortion rate, and live birth rate had no difference between the G-CSF group and the control group (P ≥ 0.05).

Conclusion: The subcutaneous administration of G-CSF had no positive effect on pregnancy outcomes in RIF patients who underwent FET cycles. However, more research is needed.