Volume 59, Number 3, June2014

  Editorial
185
Lawrence D. Devoe, M.D.
 
 
 


  Symposium
  Gestational Trophoblastic Disease: Presentations from the XVIth World Congress on Gestational Trophoblastic Diseases
187
Ross S. Berkowitz, M.D., Neil S. Horowitz, M.D., and Donald P. Goldstein, M.D.
 
 
 


188
Roberto Vargas, M.D., Lisa M. Barroilhet, M.D., Katharine Esselen, M.D., M.B.A., Elisabeth Diver, M.D., Marilyn Bernstein, M.H.P., Donald P. Goldstein, M.D., and Ross S. Berkowitz, M.D.
Patients affected by complete and partial molar pregnancy, as well as gestational trophoblastic neoplasia, should expect subsequent pregnancy outcomes similar to the general population.
 
 


195
Jane Ireson, R.G.N., Kamaljit Singh, R.G.N., Sarah Gillett, R.G.N., Annie Hills, R.G.N., Jan Everard, R.G.N., Matthew Winter, M.D., Robert E. Coleman, M.D., John Tidy, M.D., and Barry W. Hancock, M.D.
The development of the nursing role within a centralized, multidisciplinary organization has proved of convincing benefit in the clinical and holistic care of patients with gestational trophoblastic disease in the United Kingdom.
 
 


199
Emma L. Barber, M.D., Julian C. Schink, M.D., and John R. Lurain, M.D.
Survival of patients with hepatic metastasis of gestational trophoblastic neoplasia is adversely affected by the presence of concomitant intraabdominal or brain metastasis.
 
 


204
Jacqueline M. K. Wong, B.Sc., Dachao Liu, M.S., and John R. Lurain, M.D.
Multiagent EMA-CO chemotherapy for high-risk gestational trophoblastic neoplasia does not significantly alter menstrual or reproductive outcomes as compared to single-agent methotrexate chemotherapy for low-risk gestational trophoblastic neoplasia.
 
 


209
Rafael Cort�s-Charry, M.D., Nicol Corredor, M.D., Jessica Fern�ndez, M.D., Aleydah Salazar, M.D., Lourdes Rodriguez, M.D., and Margarita Fargione, M.L.
The measurement of hCG 3 weeks after a nonmolar pregnancy is an effective and inexpensive means to evaluate the possibility of retained placental tissue or gestational trophoblastic disease.
 
 


213
Gemma Petts, M.B.B.S., Rosemary A. Fisher, Ph.D., Dee Short, B.Sc. Ian Lindsay, F.R.C.Path., Michael J. Seckl, F.R.C.P., and Neil J. Sebire, F.R.C.Path.
When assessed in an unbiased, blinded manner, no morphological or immunohistochemical findings in complete hydatidiform mole can reliably predict development of persistent gestational trophoblastic disease.
 
 


221
Ying Liu, M.D., Junjun Yang, M.D., Tong Ren, M.D., Jun Zhao, M.D., Fengzhi Feng, M.D., Xirun Wan, M.D., and Yang Xiang, M.D.
Surgery combined with the appropriate chemotherapy regimen can improve therapeutic efficacy and survival in the treatment of nongestational ovarian choriocarcinoma with lung metastasis, even in recurrent or chemorefractory cases.
 
 


227
Vilmos F�l�p, M.D., Ph.D., D.Sc., Iv�n Szigetv�ri, M.D., J�nos Szepesi, M.D., Gy�rgy V�gh, M.D., and Ross S. Berkowitz, M.D.
Complete remission was achieved in 95.7% of patients with high-risk gestational trophoblastic neoplasia at the National Trophoblastic Disease Center of Hungary.
 
 


235
Ma. Stephanie Fay S. Cagayan, M.D., FPOGS, FPSECP, FPSSTD
No significant change is seen with the clinical profile and course of hydatidiform mole in the Philippines for the past two decades.
 
 


241
Antonio Braga, M.D., Ph.D., Elza Maria Hartmann Uberti, M.D., Ph.D., Maria do Carmo Fajardo, M.D., Maur�cio Viggiano, M.D., Sue Yazaki Sun, M.D., Ph.D., Bruno Maurizio Grillo, M.D., S�rgio Lunardon Padilha, M.D., Jurandyr Moreira de Andrade, M.D., Ph.D., Christiani Bisinoto de Souza, M.D., Jos� Mauro Madi, M.D., Ph.D., Izildinha Maest�, M.D., Ph.D., and Eduardo Silveira, M.D.
The authors analyze the clinical epidemiology of GTD in Brazilian referral centers in order to correlate its histological diagnosis and development into GTN, estimate GTN prevalence in all referral centers included in the study, describe patient compliance with the recommended postmolar follow-up, and calculate survival rates.
 
 


248
Jennet Williams, M.D., Dee Short, B.Sc., Linda Dayal, B.Sc., Sarah Strickland, B.Sc., Richard Harvey, Ph.D., Terry Tin, M.Sc., Philip M. Savage, M.D., Ph.D., and Michael J. Seckl, M.D., Ph.D.
The authors report on the effects of conception within 12 months of completing treatment for GTN on pregnancy outcome and relapse in a cohort of 1,204 patients.
 
 


  Original Articles
255
Gary Levy, M.D., Micah Hill, D.O., Stephanie Beall, M.D., Ph.D., Justin D. Pilgrim, D.O., Mark Payson, M.D., and Anthony Propst, M.D.
Falling estradiol levels during assisted reproductive technology cycles after administration of hCG trigger are not predictive of poor oocyte maturity or decreasing pregnancy rates.
 
 


260
Berna Seckin, M.D., Figen Turkcapar, M.D., Yunus Yildiz, M.D., Bahar Senturk, M.D., Nafiye Yilmaz, M.D., and Cavidan Gulerman, M.D.
Luteal phase support with vaginal progesterone improves reproductive outcomes of rFSH-stimulated IUI cycles with multifollicular response, but not with monofollicular response.
 
 


267
Michael DiMattina, M.D., John David Gordon, M.D., Awie Botes, B.Sc., Gerald Celia, Ph.D., Mark Payson, M.D., and Jennifer Graves-Herring, Ph.D.
The authors established threshold follicular and estradiol parameters that improved success in 821 cycles of natural cycle IVF.
 
 


274
Bei Cheng, M.D., Zhi Xia Liu, M.D., Wei Zhou, M.D., and Jian Hua Qian, M.D.
In an analysis of fertility-sparing surgery in 36 patients with gestational trophoblastic neoplasia, all 32 patients who followed up achieved remission after a combination of surgery and chemotherapy, and 25 patients retained fertility.
 
 


279
Dotun Ogunyemi, M.D., Sukrant Mehta, M.D., Aaron Turner, M.D., David Kim, M.D., and Carolyn Alexander, M.D.
Emotional intelligence scores correlated positively with Collaborating conflict style and Assertive behaviors but negatively with Dominance personality domain; medical students had significantly lower Social Awareness scores when compared to residents.
 
 


285
Qian Zhang, M.Sc., Junhao Yan, M.D., Ph.D., Rong Tang, M.D., Ph.D., Xuan Gao, B.S.M., Bo Zhang, M.D., Ph.D., and Zi-Jiang Chen, M.D., Ph.D.
Serum hCG levels measured on the 17th day after oocyte retrieval in IVF/ICSI treatment cycles are clinically useful in predicting final clinical pregnancy outcomes.
 
 


293
Marwan M. Ali, M.D., Megan Brown, M.P.H., and V. Joseph Karnitis, M.D.
Insulin levels during third trimester screening are not correlated with fetal macrosomia or delivery complications, adding no predictive value to the glucose screening test.
 
 


299
Jay M. Berman, M.D., David P. Krewson, D.O., Jeffrey M. Livingston, M.D., Doreen Moser, D.O., and Melanie K. Schultz, M.D.
The Genesys hydrothermal ablation system delivers a safe and reliable treatment option for premenopausal women with heavy menstrual bleeding.
 
 


306
Petra M. Casey, M.D., Margaret E. Long, M.D., Linda B. Drozdowicz, B.S., Mary L. Marnach, M.D., and Amy L. Weaver, M.S.
Reassurance plus doxycycline is associated with lower removal rates for etonogestrel subdermal implant�related bleeding than is reassurance alone.
 
 


313
LaTasha B. Craig, M.D., Lee E. Hullender Rubin, D.A.O.M., L.Ac., Jennifer D. Peck, Ph.D., Michael Anderson, Ph.D., Lorna A. Marshall, M.D., and Michael R. Soules, M.D.
Acupuncture using a modified Paulus protocol before and after fresh embryo transfer was found to lower clinical pregnancy and delivery rates. While not disproving acupuncture as a valid therapy in ART treatment cycles, the study calls into question the efficacy and propriety of the standardized acupuncture treatment application when performed off-site on the same day as embryo transfer.
 
 


321
Berna Seckin, M.D., Gulnur Ozaksit, M.D., Ayla Sargin Oruc, M.D., and Nafiye Yilmaz, M.D.
Luteal supplementation with rLH combined with vaginal progesterone does not appear to improve pregnancy outcomes in high responder patients undergoing long GnRH agonist IVF treatments.
 
 


  Case Reports
327
Adam Ostrzenski, M.D., Ph.D., Dr.Hab.
Anterior vaginal introital defect(s) can cause an acquired sensation of wide vagina.
 
 


330
Debra S. Heller, M.D., Karen Houck, M.D., Edward S. Lee, M.D., and Mark S. Granick, M.D.
Primary clear cell adenocarcinoma of the abdominal wall is exceptionally rare and most likely arises within scar endometriosis. Fine needle aspiration may be helpful in establishing the diagnosis.
 
 


333
Joseph R. Wax, M.D., Michael G. Pinette, M.D., Daniel Rausch, M.D., and Angelina Cartin
May-Thurner syndrome is an underappreciated cause of deep venous thrombosis in reproductive-aged women. Awareness may lead to improved recognition, treatment, and fewer long-term sequelae.
 
 


337
Mohamad S. Mahmoud, M.D., FACOG
It is important to consider looking for a maldescended ovary whenever a patient has a M�llerian and/or kidney anomaly with absence of one or both ovaries on pelvic imaging.